Anti-angiogenesis Therapy

vessels

Numerous diseases are associated with abnormal or excessive angiogenesis, among them ocular diseases, cancer, rheumatoid arthritis, vascular malformations, diabetic nephropathy, and obesity, to name a few. Anti-angiogenic therapies have shown efficacy in ocular diseases and cancer. We are developing the next generation anti-angiogenic and anti-lymphangiogenic therapies that combine short therapeutic biomimetic peptides with delivery by biodegradable phagocytosis-resistant micro- and nanoparticles. We envision numerous applications of these novel therapeutics as monotherapies or in combination with existing drugs.

 

Ophthalmology

Age-Related Macular Degeneration
Eye

Neovascular Age-Related Macular Degeneration (also known as “wet” AMD) is the most prevalent cause of severe vision less in the elderly.  This condition affect more than 1.75 million people in the United States and more than 12 million people worldwide.  Due to the aging population, the incidence of Neovascular Age-Related Macular Degeneration is forecasted to increase by 50% by the year 2020.  Current therapies are ineffective for some patients and the frequent injections required are a burden and carry a safety risk for all patients.  AsclepiX Therapeutics addresses this in two main ways:

  • A peptide drug agent that blocks both VEGF and non-VEGF signaling and can cause both inhibition of new neovasculature as well as regression of existing vasculature.
  • A delivery system that ensures long-term controlled release of the peptide drug over time.

 

Oncology

tumor

Solid tumors are dependent on angiogenesis for delivery of oxygen and nutrients required for their growth and metastasis. Tumor cells migrate into blood and lymphatic vessels and disseminate to other organs and tissues where they can originate metastatic growth.

AsclepiX platform technologies are applied to create cancer-specific anti-angiogenic and anti-lymphangiogenic nanomedicines to be used as neoadjuvant and adjuvant therapies to inhibit tumor growth and metastasis.

 

 

 

Immunology

AsclepiX Therapeutics in leveraging recently developed immunomodulatory technology to regulate the immune system and improve the safety and efficacy of tissue transplantation.