Co-founded by Aleksander S. Popel, PhD and Jordan J. Green, PhD at Johns Hopkins University, AsclepiX is building a company and culture focused on transforming the treatment of disease in ophthalmology and oncology.
To date, anti-VEGF treatment has been the gold standard for treating retinal disease; however, many patients do not have a complete and lasting response with currently approved therapies. In patients who do respond, the short duration of action of these treatments requires the additional burden of recurring and frequent intravitreal injections. There is a need for more efficacious medicines that require fewer injections and reduces the treatment burden for patients.
Our mission is to go well beyond the capabilities of today’s therapies. We do this by translating brilliant scientific discovery into tomorrow’s transformative medicines that have the potential to bring better and dramatically lasting health to people throughout the world.
In ophthalmology, we are initially focused on three of the leading causes of blindness in adults: diabetic macular edema (DME), neovascular (wet) age-related macular degeneration (wet AMD), and macular edema following retinal vein occlusion (RVO). In addition to a novel mechanism of action in the treatment of these diseases, we seek to achieve superior efficacy with significantly fewer injections than approved therapies, substantially reducing the treatment burden for patients.
In oncology, we are developing treatments to activate anti-tumor immunity, inhibit metastasis, and enhance efficacy in combination with immunotherapy and chemotherapy. Early results in animal models show inhibition of tumor growth and improved survival in triple-negative breast cancer and hepatocellular carcinoma and inhibition of metastasis in triple-negative breast cancer.
We are dedicated every day to advancing the clinical development of these novel therapeutics to prove their safety and efficacy in fulfilling significant unmet needs in global healthcare.
Prior to TherOptix, Amir served as the Chief Development Officer for TearClear leading clinical development and regulatory strategy of all pipeline and late-stage assets. Before joining TearClear, Amir spent just under 20 years at Shire until it was acquired by Takeda in Jan 2019. At Shire, he helped create the ophthalmology franchise as the Global Therapeutic Area Head in Ophthalmology and was later able to successfully divest the key asset in that franchise, Xiidra, to Novartis for $5.3 Billion. While at Shire, Amir oversaw all aspects of clinical stage ophthalmic pipeline assets. His team brought Xiidra® (lifitegrast) from development through to U.S. FDA filing and approval. Amir’s active engagement in the clinical development around design and implementation of OPUS-3 as well as the analysis of totality of evidence were pivotal in the negotiations with the FDA leading to a US approval in July 2016.
Amir is also an independent Board member at iVeena Inc., ForwardVue Inc., and a member of the Scientific Advisory Board of Ophthalmology for HTL Biotechnology, France.
Prior to the start of his industry career, Amir was in academia, Texas Tech University and University of Alberta, as tenure track assistant professor teaching and training graduate students as well as post-doctoral fellows in pharmaceutical sciences and transmucosal drug delivery. He earned his Doctor of Philosophy degree and his Doctor of Pharmacy degree (magna cum laude) from the University of the Pacific, Stockton, California and holds a Bachelor of Science from the University of Alberta, Edmonton, AB, Canada.
Prior to HB and B&S, Josh has spent his career at several boutique investment banks and consultancies, including Trout Capital and the Maxim Group, and has a passion for early-stage drug development to serve patients with unmet medical needs. He is also a Venture Advisor at the Israel Biotech Fund.
Josh is on the boards of Asclepix, Inc. and NexImmune, Inc. (board observer). He is also on the Boards of several-not for-profit organizations focused on education and economic development, including Trickle Up, Family Promise, and Getting Out and Staying Out (Action Board).
Josh received a Bachelor of Arts from Rutgers College and studied Conflict Management at Drew University.